Anidulafungin (LY303366)

Description: Anidulafungin (formerly also named LY303366), a novel semisynthetic echinocandin derivative, which inhibits glucan synthase activity, used as an antifungal drug. Anidulafungin has been reported to inhibit systemic isolates of Candida species with the MIC90 values of 0.08ug/ml, 0.32ug/ml, 0.32ug/ml and 5.12ug/ml for C.albicans (n=99), C.glabrata(n=18), C.tropicalis(n=10), and C.parapsilosis (n=10), respectively. In addition, Anidulafungin has been found to be active against Aspergillus species(n=20) with the MIC90 values of ca.0.02ug/ml. Apart from these, Anidulafungin has been revealed to inactively restrain with the MIC90 values of > 10.24ug/ml and 16ug/ml, for C.neoformans and B.dermatitidis, respectively .

References: Antimicrob Agents Chemother. 1997 Apr; 41(4):863-5.