Rilmenidine Phosphate

Description: Rilmenidine Phosphate, the water soluble form of Rilmenidine, is a potent and selective imidazoline receptor agonist used for the treatment of hypertension. In Hep G2 cells treated with 0.5 mM oleic acid for 6 hours and 1um Rilmenidine for 30 minutes, the oleic acid-induced lipid accumulation decreases. Stimulation of imidazoline I-1 receptor by Rilmenidine activated P38 to induce the expression of FXR. Mice fed with HFD (high fat diet) had improved hepatic steatosis following the administration of Rilmenidien through the activation of imidazoline I-1 receptor.

References: Am J Hypertens. 1992 Apr; 5(4 Pt 2):99S-105S; Annu Rev Pharmacol Toxicol. 1996; 36:511-44.

Related CAS: 85409-38-7 (phosphate); 54187-04-1 (free base); 207572-68-7 (hemifumarate)