GSK547

ArtNr	V2059-10mg
Hersteller	InvivoChem LLC
CAS-Nr.	2226735-55-1
Menge	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Lieferbar
Description	InvivoChem Cat #:V2059CAS #:2226735-55-1 Purity >=98% Description: GSK'547 is a novel, potent and highly selective inhibitor of RIP1 (receptor-interacting serine/threonine protein kinase 1) which exhibits a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963. Targeting RIP1 reprogrammed TAMs (tumor-associated macrophages) toward an MHCIIhiTNFalpha+IFNgamma+ immunogenic phenotype in a STAT1-dependent manner. RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human PDA. Targeting RIP1 synergized with PD1-and inducible co-stimulator-based immunotherapies. Tumor-promoting effects of RIP1 were independent of its co-association with RIP3. Collectively, our work describes RIP1 as a checkpoint kinase governing tumor immunity. References: Cancer Cell. 2018 Nov 12; 34(5):757-774.e7.
	Name: GSK547 CAS#: 2226735-55-1 Chemical Formula: C20H18F2N6O Exact Mass: 396.151 Molecular Weight: 396.4 Elemental Analysis: C, 60.60; H, 4.58; F, 9.59; N, 21.20; O, 4.04
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GSK'547; GSK547; GSK-547; GSK 547; RIP1i Chemical Name: (S)-6-(4-(5-(3, 5-difluorophenyl)-4, 5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile InChi Key: SJVGFKBLUYAEOK-SFHVURJKSA-N InChi Code: InChI=1S/C20H18F2N6O/c21-15-7-14(8-16(22)9-15)18-1-4-26-28(18)20(29)13-2-5-27(6-3-13)19-10-17(11-23)24-12-25-19/h4, 7-10, 12-13, 18H, 1-3, 5-6H2/t18-/m0/s1 SMILES Code: N#CC1=NC=NC(N2CCC(C(N3N=CC[CH]3C4=CC(F)=CC(F)=C4)=O)CC2)=C1

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 10 mg

lieferbar

Lieferung vsl. bis 04.09.2025