Mardepodect hydrochloride

Description: Mardepodect HCl, the hydrochloric acid salt of PF-2545920 (Also known as Mardepodect, MP-10), is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with IC50 of 0.37 nM, and with > 1000-fold selectivity over the PDE. It is potentially useful for the treatment of schizophrenia. PF-2545920 is active in a range of antipsychotic models, antagonizing apomorphine-induced climbing in mice, inhibiting conditioned avoidance responding in both rats and mice, and blocking N-methyl-D-aspartate antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats, while improving baseline sensory gating in mice.

References: J Pharmacol Exp Ther. 2009 Nov; 331(2):574-90; J Med Chem. 2009 Aug 27; 52(16):5188-96.

Related CAS#: 1292799-56-4; 898562-94-2 (free)