ATB-346

Description: ATB-346, a structural analog of naproxen (one of the NSAIDs-Nonsteroidal anti-inflammatory drugs), is anti-inflammatory agent. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of action. Unlike naproxen, ATB-346 did not increase blood pressure in hypertensive rats. Treatement with ATB-346 achieved a significantly more rapid and sustained recovery of motor function, obtaining greater than double the increase in locomotion score of the naproxen group by the 10th day of treatment. ATB-346 also significantly reduced the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterized the secondary effects of SCI (spinal cord injury).

References: Br J Pharmacol. 2010 Mar; 159(6):1236-46.FASEB J. 2013 Nov; 27(11):4489-99