Tinoridine HCl (Y-3642 HCl)

Description: Tinoridine HCl (also known as Y-3642 HCl), the hydrochloride of tinoridine (Y-3642), is a nonsteroidal anti-inflammatory drug (NSAID) that also has potent radical scavenger and antiperoxidative activity. At concentrations from 5 uM to 100 uM, tinoridine can produce a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 uM ascorbic acid in the renin granule fraction. While other NSAIDs and steroids such as indomethacin, hydrocortisone and prednisolone do not inhibit the lipid peroxidation in the renin granule fraction, did not influence the release of renin from the granules, suggesting that tinoridine suppresses renin release by inhibiting the oxidative disintegration of membranes of renin granules.

References: Toxicol Appl Pharmacol. 1980 Mar 15; 52(3):407-13; Agents Actions. 1986 Nov; 19(3-4):208-14..