Colchicine

Description: Colchicine is a mitotic inhibitor that inhibits microtubule polymerization (also called microtubule disrupting agent or tubulin inhibitor) with IC50 of 3 nM. Colchicine is an approved drug for treating gout but is also being investigated for its anticancer activities. Colchicine promotes depolymerization of microtubules, and thus belong to the microtubule destabilizers. Colchicine, as the first tubulin destabilizing compound, was isolated from the poisonous meadow saffron Colchicum autumnale L. In 2009, colchicine was approved for the treatment of gout and familial mediterranean fever. Colchicine also demonstrated potent antimitotic and anticancer activity. However, the clinical development of colchicine as an anticancer agent was hampered due to its significant toxicity such as neutropenia, bone marrow damage, gastrointestinal upset and anemia.

References: Eur J Med Chem. 2018 May 10; 151:482-494; Pharm Res. 2012 Nov; 29(11):2943-71.

Publications Citing Use of InvivoChem Colchicine:

1) J Med Chem. 2021 Apr 22; 64(8):4498-4515. doi: 10.1021/acs.jmedchem.0c01837;

2) Eur J Med Chem. 2020 Sep 15; 202:112519. doi: 10.1016/j.ejmech.2020.112519.