Desmopressin acetate trihydrate

Description: Desmopressin acetate, the acetate salt of desmopressin (also known as DDAVP), is a synthetic octapeptide and an analogue of the human antidiuretic hormone arginine vasopressin. Compare with vasopressin, Desmopressin has improved pharmacokinetics such as prolonged half life and better pharmacodynamics such as higher selectivity for the V2 membrane receptor. Vasopressin is a hormone that reduces the production of urine and desmopressin is a synthetic version for vasopressin. The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor. Desmopressin is most frequently prescribed for treatment of diabetes insipidus or nocturnal enuresis.

References: Thromb Haemost. 2010 Nov; 104(5):984-9; Curr Pharm Biotechnol. 2011 Nov; 12(11):1974-80.