Fabomotizole hydrochloride (CM-346; Afobazole)

Description: Fabomotizole hydrochloride (CM346; Afobazole) is a novel and selective anxiolytic drug that produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. It was launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety.

References: Bull Exp Biol Med. 2017 Feb; 162(4):441-444; Bull Exp Biol Med. 2017 Jun; 163(2):180-183.

Related CAS #: 173352-39-1 (HCl) 173352-21-1 (free base)