NOD-IN-1

Description: NOD-IN-1 is a novel and potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors with IC50 of 5.74 uM and 6.45 uM for NOD1 and NOD2, respectively. It displayed a balanced inhibitory activity on both targets in the low micromolar range. NOD1 and NOD2 are important members of the pattern recognition receptor family and play a crucial role within the context of innate immunity. However, overactivation of NODs, especially of NOD1, has also been implicated in a number of diseases. Surprisingly, NOD1 remains a virtually unexploited target in this respect.

References: Bioorg Med Chem. 2016 Nov 1; 24(21):5221-5234.