GSK-962

ArtNr	V3291-10mg
Hersteller	InvivoChem LLC
CAS-Nr.	2049872-86-6
Menge	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Lieferbar
Description	InvivoChem Cat #:V3291CAS #:2049872-86-6Purity >=98% Description: GSK-962 (also known as GSK'962 or GSK962) is a negative control for GSK'963 (also known as GSK'963 or GSK963). GSK-963 is a potent and selective RIP1 kinase inhibitor. GSK'963 is significantly more potent than Nec-1 (a known RIP1 kinase inhibitor ) in both biochemical and cellular assays, inhibiting RIP1-dependent cell death with an IC50 of between 1 and 4?nM in human and murine cells. GSK'963 is > 10?000-fold selective for RIP1 over 339 other kinases, lacks measurable activity against IDO and has an inactive enantiomer, GSK'962, which can be used to confirm on-target effects. The increased in vitro potency of GSK'963 also translates in vivo, where GSK'963 provides much greater protection from hypothermia at matched doses to Nec-1, in a model of TNF-induced sterile shock. Together, we believe GSK'963 represents a next-generation tool for examining the function of RIP1 in vitro and in vivo, and should help to clarify our current understanding of the role of RIP1 in contributing to disease pathogenesis. Description: References: Cell Death Discov. 2015 Jul 27; 1:15009. References: Related CAS #: 2049868-46-2 (GSK-963)
Molecular Weight (MW)	230.31
Formula	C14H18N2O
CAS No.	2049872-86-6 (GSK-962); 2049868-46-2 (GSK-963)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	2, 2-Dimethyl-1-(5(R)-phenyl-4, 5-dihydro-pyrazol-1-yl)-propan-1-one
Synonyms	GSK-962; GSK 962; GSK962; GSK'962; GSK' 962
SMILES Code	CC(C)(C)C(N1N=CC[CH]1C2=CC=CC=C2)=O

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkt-Datenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 10 mg

lieferbar

Lieferung vsl. bis 04.09.2025

Express-Lieferung: 2 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern