AMG-176

InvivoChem Cat #:V3448CAS #:1883727-34-1Purity >=98%

Description: AMG-176 is a novel, potent, selective and orally bioavailable inhibitor of MCL-1 (myeloid cell leukemia-1) with a Ki of 0.13 nM. AMG-176 has potential pro-apoptotic and antineoplastic activities. AMG 176 binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.

References: Cancer Discov. 2018 Sep 25. pii: CD-18-0387.; Curr Opin Chem Biol. 2017 Aug; 39:133-142.

-20C for 3 years in powder form

Synonym: AMG-176; AMG 176; AMG176.
Chemical Name: Spiro[5, 7-etheno-1H, 11H-cyclobut[i][1, 4]oxazepino[3, 4-f][1, 2, 7]thiadiazacyclohexadecine-2(3H), 1'(2'H)- naphthalen]-8(9H)-one, 6'-chloro-3', 4', 12, 13, 16, 16a, 17, 18, 18a, 19-decahydro-16-methoxy-11, 12-dimethyl- , 10, 10-dioxide, (1'S, 11R, 12S, 14E, 16S, 16aR, 18aR)-
InChi Key: JQNINBDKGLWYMU-GEAQBIRJSA-N
InChi Code: InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38, 39)22(21)2/h4, 8, 10-11, 13-14, 16-17, 21-22, 25, 27, 30H, 5-7, 9, 12, 15, 18-20H2, 1-3H3, (H, 35, 37)/b8-4+/t21-, 22+, 25-, 27+, 30-, 33-/m0/s1
SMILES Code: O=C(N1)C2=CC(N(C[CH]3[CH](CC3)[CH](OC)/C=C/C[CH](C)[CH](C)S1(=O)=O)C4)=C(C=C2)OC[C]54CCCC6=CC(Cl)=CC=C65