Entecavir (SQ 34676)

ArtNr	V3511-5mg
Hersteller	InvivoChem LLC
CAS-Nr.	142217-69-4
Menge	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	142217-69-4
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Description	InvivoChem Cat #:V3511CAS #:142217-69-4 (free); 209216-23-9 (hydrate); 911138-73-3 (maleate) Purity >=98% Description: Entecavir (also known as SQ 34676 and BMS 200475), anti-hepatitis B virus (HBV) agent, is a novel deoxyguanine nucleosideanalogue and a reverse transcriptase inhibitor. Entecavir is a potentand selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cells.It is an oral antiviral drug used in the treatment of hepatitis B virus(HBV) infection. It prevents the hepatitis B virus from multiplying andreduces the amount of virus in the body. Entecavir is a highly potentinhibitor of wild-type HBV Pol and is 100- to 300-fold more potent thanlamivudine-triphosphate against 3TC-resistant HBV Pol. Entecavirinhibits the replication of 3TC-resistant HBV, but 20- to 30-fold higherconcentrations are required. , anti-hepatitis B virus (HBV) agent, is a novel deoxyguanine nucleosideanalogue and a reverse transcriptase inhibitor. Entecavir is a potentand selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cells.It is an oral antiviral drug used in the treatment of hepatitis B virus(HBV) infection. It prevents the hepatitis B virus from multiplying andreduces the amount of virus in the body. Entecavir is a highly potentinhibitor of wild-type HBV Pol and is 100- to 300-fold more potent thanlamivudine-triphosphate against 3TC-resistant HBV Pol. Entecavirinhibits the replication of 3TC-resistant HBV, but 20- to 30-fold higherconcentrations are required. References: Antimicrob Agents Chemother. 2002 Aug; 46(8):2525-32; Antimicrob Agents Chemother. 2003 Aug; 47(8):2624-35. Related CAS#: 142217-69-4 (free); 911138-73-3 (maleate); 209216-23-9 (hydrate)
Molecular Weight (MW)	277.28
Formula	C12H15N5O3
CAS No.	209216-23-9 (hydrate); 142217-69-4 (free); 911138-73-3 (maleate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 40 mg/mL
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
SMILES	O=C1NC(N)=NC2=C1N=CN2[CH]3C([CH](CO)[CH](O)C3)=C.[H]O[H]
Synonyms	BMS-200475; BMS 200475; BMS200475; BMS 200475-01; BMS-200475-01; Entecavir monohydrate; Baraclude; D07896

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