MZ1

InvivoChem Cat #:V3580CAS #:1797406-69-9 Purity >=98%

Description: MZ 1 is a novel and potent PROTAC-based degrader of BRD4 protein. Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase-PROTAC-target species and its impact on target degradation selectivity remain elusive.

References: Nat Chem Biol. 2017 May; 13(5):514-521.

-20C for 3 years in powder form

Synonym: MZ1; MZ-1; MZ 1.
Chemical Name: 1-[2(S)-(2-{2-[2-(2-{2-[4-(4-Chloro-phenyl)-2, 3, 9-trimethyl-6H-1-thia-5, 7, 8, 9a-tetraaza-cyclopenta[e]azulen-6(S)-yl]-acetylamino}-ethoxy)-ethoxy]-ethoxy}-acetylamino)-3, 3-dimethyl-butyryl]-pyrrolidine-2(S)-carboxylic acid 4-(4-methyl-thiazol-5-yl)-benzylamide
InChi Key: IHNPXDBPGMBPCY-BAVOTMDYSA-N
InChi Code: InChI=1S/C49H60ClN9O7S2/c1-29-31(3)68-48-41(29)42(34-14-16-36(50)17-15-34)54-37(45-57-56-32(4)59(45)48)25-39(60)51-18-20-64-21-22-65-23-24-66-27-40(61)55-44(49(5, 6)7)47(63)58-19-8-9-38(58)46(62)52-26-33-10-12-35(13-11-33)43-30(2)53-28-67-43/h10-17, 28, 37-38, 44H, 8-9, 18-27H2, 1-7H3, (H, 51, 60)(H, 52, 62)(H, 55, 61)/t37-, 38-, 44+/m0/s1
SMILES Code: O=C([CH]1N(C([CH](NC(COCCOCCOCCNC(C[CH]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)C(C)(C)C)=O)CCC1)NCC6=CC=C(C7=C(C)N=CS7)C=C6