Bay 65-1942 HCl

InvivoChem Cat #:V4192CAS #:600734-06-3Purity >=98%

Description: Bay 65-1942 HCl is the hydrochloride salt of of BAY65-1942 which is a novel, potent and selective ATP-competitive inhibitor of IKKbeta. It selectively targets IKKbeta kinase activity. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Animals pretreated with Bay 65-1942 (n=3) have significantly attenuated CK-MB levels compared with those animals without treatment prior to IR (14, 170 +/-3, 219 units, P< 0.05 vs. vehicle)

Description:

References: Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2248-53.; PLoS One. 2013 Jun 24; 8(6):e66755.

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Related CAS#:758683-21-5 (BAY65-1942 R-isomer); 600734-02-9 (free base);

-20C for 3 years in powder form

Synonym: BAY 65-1942 HCl; BAY-65-1942 hydrochloride; BAY65-1942; BAY 651942; BAY-651942; BAY651942
IUPAC/Chemical Name: (S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1, 4-dihydro-2H-pyrido[2, 3-d][1, 3]oxazin-2-one hydrochloride
InChi Key: IGJVFGZEWDGDOO-CQSZACIVSA-N
InChi Code: InChI=1S/C22H25N3O4/c26-18-4-1-5-19(28-11-13-6-7-13)20(18)17-9-15(14-3-2-8-23-10-14)16-12-29-22(27)25-21(16)24-17/h1, 4-5, 9, 13-14, 23, 26H, 2-3, 6-8, 10-12H2, (H, 24, 25, 27)/t14-/m1/s1
SMILES Code: O=C1OCC2=C([CH]3CNCCC3)C=C(C4=C(O)C=CC=C4OCC5CC5)N=C2N1.[H]Cl