AZD5423

InvivoChem Cat #:V4250CAS #:1034148-04-3Purity >=98%

Description: AZD5423 is the first clinical candidate that displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect, assessed as thymic involution. Further optimization of inhaled drug properties provided a second, equally potent, candidate, AZD7594 (also known as AZ13189620), which is a novel, potent selective nonsteroidal indazole ether-based glucocorticoid receptor modulators (SGRMs) with an IC50 of 0.9 nM. AZD-7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator for the inhaled treatment of respiratory diseases. AZD7594 demonstrated an improved therapeutic ratio over the benchmark inhaled corticosteroid 3 (fluticasone propionate) and prolonged the inhibition of lung edema, indicating potential for once-daily treatment. AZD-7594 is currently in phase II clinical trials by AstraZeneca for the treatment of mild to moderate asthma. It is also in phase I clinical trials for the treatment of chronic obstructive pulmonary disorder (COPD).

Description:

References: J Med Chem. 2017 Oct 26; 60(20):8591-8605.

References:

-20C for 3 years in powder form

Synonym: AZD-5423; AZD 5423; AZD5423; UNII-641H0Q518W;
IUPAC/Chemical Name: 2, 2, 2-Trifluoro-N-((1R, 2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)-2-propanyl)acetamide
InChi Key: FCNQMDSJHADDFT-WNSKOXEYSA-N
InChi Code: InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27, 28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15, 23H, 1-2H3, (H, 31, 33)/t15-, 23-/m0/s1
SMILES Code: C[CH]([CH](c1cccc(c1)OC)Oc2ccc3c(c2)cnn3c4ccc(cc4)F)NC(=O)C(F)(F)F
InChi Code: InChI=1S/C32H32F2N4O6/c1-19(36-31(40)32(2, 33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9, 14-17, 19, 23, 29H, 10-13, 18H2, 1-2H3, (H, 36, 40)(H, 37, 39)/t19-, 23?, 29-/m0/s1
SMILES Code: O=C(NC1COCC1)C2=CC=CC(N3N=CC4=C3C=CC(O[CH](C5=CC=C(OCCO6)C6=C5)[CH](NC(C(F)(F)C)=O)C)=C4)=C2