VAPREOTIDE ACETATE

InvivoChem Cat #:V4358CAS #:849479-74-9 Purity >=98%

Description: Vapreotide acetate (trade name: Sanvar) is a synthetic somatostatin analog and a NK1R antagonist with an IC50 of 330 nM. It is used in the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and AIDS-related diarrhea. It is an 8 residue peptide with sequence H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2.

References: Neuroimmunomodulation. 2013; 20(5):247-55.

Related CAS#:103222-11-3 (free); 936560-75-7 (Vapreotide diacetate)

-20C for 3 years in powder form

Synonym: BMY-41606; BMY 41606; BMY41606; RC160; RC 160; RC-160; DP-05-094; Octastatin; Vapreotide acetate
IUPAC/Chemical Name: (4R, 7S, 10S, 13S, 16S, 19R)-13-((1H-indol-3-yl)methyl)-N-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-19-((R)-2-amino-3-phenylpropanamido)-10-(4-aminobutyl)-16-(4-hydroxybenzyl)-7-isopropyl-6, 9, 12, 15, 18-pentaoxo-1, 2-dithia-5, 8, 11, 14, 17-pentaazacycloicosane-4-carboxamide acetate
InChi Key: KBIZSMHYSQUHDH-CYKDYWLUSA-N
InChi Code: InChI=1S/C57H70N12O9S2.C2H4O2/c1-32(2)49-57(78)68-48(55(76)64-44(50(60)71)26-35-28-61-41-16-8-6-14-38(35)41)31-80-79-30-47(67-51(72)40(59)24-33-12-4-3-5-13-33)56(77)65-45(25-34-19-21-37(70)22-20-34)53(74)66-46(27-36-29-62-42-17-9-7-15-39(36)42)54(75)63-43(52(73)69-49)18-10-11-23-58; 1-2(3)4/h3-9, 12-17, 19-22, 28-29, 32, 40, 43-49, 61-62, 70H, 10-11, 18, 23-27, 30-31, 58-59H2, 1-2H3, (H2, 60, 71)(H, 63, 75)(H, 64, 76)(H, 65, 77)(H, 66, 74)(H, 67, 72)(H, 68, 78)(H, 69, 73); 1H3, (H, 3, 4)/t40-, 43+, 44+, 45+, 46+, 47+, 48+, 49+; /m1./s1
SMILES Code: CC(O)=O.O=C(N[CH](C(N[CH](C(N[CH](C(N[CH](C(N[CH](C(N1)=O)C(C)C)=O)CCCCN)=O)CC2=CNC3=C2C=CC=C3)=O)CC4=CC=C(C=C4)O)=O)CSSC[CH]1C(N[CH](C(N)=O)CC5=CNC6=C5C=CC=C6)=O)[CH](N)CC7=CC=CC=C7