CILASTATIN

InvivoChem Cat #:V4386CAS #:82009-34-5Purity >=98%

Description: Cilastatin (also known as MK0791) is a renal dehydropeptidase inhibitor. It is also a leukotriene D4 dipeptidase inhibitor. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria.

References: Antimicrob Agents Chemother. 1995 Jul; 39(7):1629-31.

Related CAS#: 81129-83-1 (sodium)

-20C for 3 years in powder form

Synonym: MK-0791; MK 0791; MK0791; Cilastatina; Cilastatine; Cilastatinum; Cilastatin Monosodium Salt ; Cilastatin Sodium; MK 0791; MK 791; M K-791; MK0791; MK791; Monosodium Salt, Cilastatin; Salt, Cilastatin Monosodium.
IUPAC/Chemical Name: 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2, 2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*, S*-(Z)))-
InChi Key: DHSUYTOATWAVLW-WFVMDLQDSA-N
InChi Code: InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6, 10-11H, 3-5, 7-9, 17H2, 1-2H3, (H, 18, 19)(H, 20, 21)(H, 22, 23)/b12-6-/t10-, 11+/m1/s1
SMILES Code: [CH]1(C(C1)(C)C)C(=O)N/C(=C\CCCCSC[CH](C(=O)O)N)C(=O)O