sb-423562

InvivoChem Cat #:V4616CAS #:351490-72-7 (HCl)Purity >=98%

Description: SB-423562 is a novel and potent short-acting calcium-sensing receptor (CaR) antagonist. Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. SB-423562 elicits transient PTH release from the parathyroid gland in several preclinical species and in humans. In an ovariectomized rat model of bone loss, daily oral administration of SB-423557 promoted bone formation and improved parameters of bone strength at lumbar spine, proximal tibia and midshaft femur. Chronic administration of SB-423557 did not increase parathyroid cell proliferation in rats. In healthy human volunteers, single doses of intravenous SB-423562 and oral SB-423557 elicited transient elevations of endogenous PTH concentrations in a profile similar to that observed with subcutaneously administered PTH. Both agents were well tolerated in humans. Transient increases in serum calcium, an expected effect of increased parathyroid hormone concentrations, were observed post-dose at the higher doses of SB-423557 studied. These data constitute an early proof of principle in humans and provide the basis for further development of this class of compound as a novel, orally administered bone-forming treatment for osteoporosis.

References: Bone. 2010 Feb; 46(2):534-42.

Related CAS : 351490-72-7 (HCl); 351490-27-2 (free base); 351490-92-1 (sodium)

-20C for 3 years in powder form

Synonym: SB-423562 HCl; SB 423562 HCl; SB423562 HCl; NPSP-795; SB-423562; SB-423562-A; SHP-635; SB-423562A; NPSP795; SB423562; SB423562A; SHP635; SB423562A; NPSP 795; SB 423562; SB 423562 A; SHP 635; SB 423562A
IUPAC/Chemical Name: (R)-3-(4-cyano-3-(3-((1-(2, 3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)phenyl)propanoic acid hydrochloride
InChi Key: WVXHWCHBKCXTJA-GNAFDRTKSA-N
InChi Code: InChI=1S/C26H32N2O4.ClH/c1-26(2, 14-19-11-20-5-3-4-6-21(20)12-19)28-16-23(29)17-32-24-13-18(8-10-25(30)31)7-9-22(24)15-27; /h3-7, 9, 13, 19, 23, 28-29H, 8, 10-12, 14, 16-17H2, 1-2H3, (H, 30, 31); 1H/t23-; /m1./s1
SMILES Code: O=C(O)CCC1=CC=C(C#N)C(OC[CH](O)CNC(C)(C)CC2CC3=C(C=CC=C3)C2)=C1.[H]Cl