cg-806

InvivoChem Cat #:V4774CAS #:1370466-81-1Purity >=98%

Description: CG-806 (also known as CG-026806) is a novel, highly potent, non-covalent/reversible small molecule, pan FLT3/BTK Multi-Kinase inhibitor. It exhibited a picomolar IC50 toward the FMS-like tyrosine kinase 3 with the Internal Tandem Duplication (FLT3-ITD and single-digit nanomolar IC50’s against Bruton’s tyrosine kinase (BTK) and its C481S mutant (BTK-C481S)). Further, CG-806 is a multi-targeted BTK / FLT3-ITD inhibitor as it impacts other relevant oncogenic targets, including the Aurora kinases (AURK), RET, MET, DDR2, and SRC kinases. CG-806 is currently being developed by Aptose Biosciences.

References: http://www.bloodjournal.org/content/130/Suppl_1/4629?sso-checked=true

-20C for 3 years in powder form

Synonym: CG-026806; CG 026806; CG026806; CG-806; CG 806; CG806;
IUPAC/Chemical Name: 1-(3-fluoro-4-(7-(4-methyl-1H-imidazol-2-yl)-1-oxoisoindolin-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
InChi Key: BOLRZWTVMUHQQU-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H19F4N5O2/c1-13-11-31-23(33-13)19-8-7-17(20-12-32-24(36)22(19)20)18-6-5-16(10-21(18)27)35-25(37)34-15-4-2-3-14(9-15)26(28, 29)30/h2-11H, 12H2, 1H3, (H, 31, 33)(H, 32, 36)(H2, 34, 35, 37)
SMILES Code: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C3=CC=C(C4=NC(C)=CN4)C5=C3CNC5=O)C(F)=C2