arfolitixorin

InvivoChem Cat #:V5028CAS #:31690-11-6 (free)Purity >=98%

Description: Arfolitixorin, an intravenously administered folate-based compound, is a novel and potent antifolate modulator that is being developed by Isofol Medical AB, for the treatment of cancer. Arfolitixorin, 6R-5, 10-methylene-tetrahydrofolic acid, is being developed to increase the efficacy of 5-FU, which has been shown to be a cytotoxic agent, as well as a rescue drug after methotrexate treatment. Arfolitixorin is the key active metabolite in leucovorin and levoleucovorin and does not require metabolic activation to exert effect.

References: https://www.targetedonc.com/news/first-patient-enrolled-in-phase-iii-study-of-novel-agent-arfolitixorin-in-mcrc

Related CAS #: 31690-11-6 (free); 149930-93-8 (sulfate); 154705-24-5 (sodium)

-20C for 3 years in powder form

Synonym: (6R)-5, 10-Methylene-5, 6, 7, 8-tetrahydrofolic acid; (6R)-5, 10-Methylenetetrahydrofolate; 5, 10-Methylene-(6R)-tetrahydrofolic acid;
IUPAC/Chemical Name: (4-((R)-3-amino-1-oxo-1, 2, 5, 6, 6a, 7-hexahydroimidazo[1, 5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamic acid
InChi Key: QYNUQALWYRSVHF-OLZOCXBDSA-N
InChi Code: InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4, 12-13H, 5-9H2, (H, 23, 30)(H, 28, 29)(H, 32, 33)(H4, 21, 22, 24, 25, 31)/t12-, 13+/m1/s1
SMILES Code: O=C(O)CC[CH](C(O)=O)NC(C1=CC=C(N2CN3C4=C(N=C(N)NC4=O)NC[C]3([H])C2)C=C1)=O