amiclenomycin

Description: Amiclenomycin is a naturally occuring antibiotic agent extracted from Streptomyces lavendulae subsp. amiclenomycini Okami; active against mycobacterium; activity reversed by biotin & desthiobiotin. Amiclenomycin, a natural product containing the 1-amino cyclohexa-2, 5-diene moiety is an inhibitor of 7; 8-diaminopelargonic acid aminotransferase, a pyridoxal phosphate (PLP) dependent enzyme involved in biotin biosynthesis. The postulated mechanism implies the aromatisation of the Schiff base formed between PLP and amiclenomycin.

References: Gehrke SS, Kumar G, Yokubynas NA, Cote JP, Wang W, French S, MacNair CR, Wright GD, Brown ED. Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. ACS Infect Dis. 2017 Dec 8; 3(12):955-965. doi: 10.1021/acsinfecdis.7b00149. Epub 2017 Nov 7. PubMed PMID: 29069544.