Ceftazidime (GR20263)

Description: Ceftazidime (GR-20263) is a potent, third generation, broad-spectrum beta-lactam antibiotic used as an antimicrobial agent for treating febrile neutropenia in patients with cancer. It is administered intravenously or intramuscularly. As a class, cephalosporins have activity against Gram-positive and Gram-negative bacteria. The balance of activity tips toward Gram-positive organisms for earlier generations; later generations of cephalosporins have more Gram-negative coverage. Ceftazidime is one of the few in this class with activity against Pseudomonas.

References:

1. RichardsDM, et al. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985Feb; 29(2):105-61.

2. Goodlet KJ, Nicolau DP, Nailor MD. Ceftolozane/tazobactam and ceftazidime/avibactam for the treatment of complicated intra-abdominal infections. Ther Clin Risk Manag. 2016 Dec 1; 12:1811-1826. eCollection 2016. Review. PubMed PMID: 27942218; PubMed Central PMCID: PMC5140030.

Related CAS #: 72558-82-8 (free) 73547-70-3 (HCl) 73547-61-2 (sodium) 78439-06-2 (free and hydrate)