Azaserine (CI337, O-Diazoacetyl-L-serine, P-165)

Description: Azaserine (CI-337, O-Diazoacetyl-L-serine, P-165) is a naturally occurring and diazo-based serine analogue with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent.

References: Huang JL, Yang SX. Safety of umbilical cord blood-derived mesenchymal stem cells (MSCs) following 5-azaserine induction and inhibition of human cardiac myocyte apoptosis by MSCs. Saudi Med J. 2009 Sep; 30(9):1144-9. PubMed PMID: 19750258.