HX 531

Description: HX-531 is a novel and potent antagonist of retinoid X receptors (RXR) with an IC50 value of 18 nM. It promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts. HX531 has been used in many studies of the various effects of retinoidsand RXR activity in diseases such as diabetes, Parkinson?s disease, often as a control for agonists such as Bexarotene. It was recentlyshown to promote white adipogenic differentiation and inhibit both basaland Bexarotene-induced brown adipogenic differentiation.

References:

1. Ebisawaet al(1999) Retinoid X receptor-antagonistic diazepinylbenzoic acids. Chem.Pharm.Bull. 471778 PMID: 10748721

2. Aliqueet al(2006) Vitamin A active metabolite, all-trans retinoic acid, inducesspinal cord sensitization. II. Effects after intrathecal administration. Br.J.Pharmacol. 14965 PMID: 16847438

3. Suzukiet al(2009) Docosahexaenoic acid induces adipose differentiation-relatedprotein through activation of retinoid X receptor in humanchoriocarcinoma BeWo cells. Biol.Pharm.Bull. 321177 PMID: 19571381

4. Nieet al(2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18624 PMID: 28099842