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Recombinant human Sirtuin 3/SIRT3 protein

Recombinant human Sirtuin 3/SIRT3 protein

ArtNr	NKM-ATGP0650-250ug
Hersteller	NKMAX
Menge	250 ug
Quantity options	10 ug 250 ug 50 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid
Applikationen	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Konjugat/Tag	HIS
Purity	> 95% by SDS-PAGE
Sequence	<MGSSHHHHHH SSGLVPRGSH M>SDKGKLSLQ DVAELIRARA CQRVVVMVGA GISTPSGIPD FRSPGSGLYS NLQQYDLPYP EAIFELPFFF HNPKPFFTLA KELYPGNYKP NVTHYFLRLL HDKGLLLRLY TQNIDGLERV SGIPASKLVE AHGTFASATC TVCQRPFPGE DIRADVMADR VPRCPVCTGV VKPDIVFFGE PLPQRFLLHV VDFPMADLLL ILGTSLEVEP
Citations	Schewr B., et al. (2002) J Cell Biol. 158(4):647-57. Kim H S., et al. (2010) Cancer Cell. 17(1):41-52. Kawaguchi M, et al. Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. (J Med Chem. 2019){https://pubmed.ncbi.nlm.nih.gov/31117516/} Kawaguchi M, et al. A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher. (Chembiochem. 2016){https://pubmed.ncbi.nlm.nih.gov/27542094/}
NCBI	NP_036371.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	NAD-dependent protein deacetylase sirtuin-3 mitochondrial,hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3,SIR2L3
Similar products	SIRT3, mitochondrial, SIR2L3, NAD-dependent deacetylase sirtuin-3, NAD-dependent deacetylase sirtuin-3 mitochondrial, Sirtuin3, Sirtulin3, ATGP0650-10ug, ATGP0650-20ug, ATGP0650-50ug, ATGP0650-100ug, ATGP0650-250ug, ATGP0650-500ug, ATGP0650-1mg, ATGP0650-10, ATGP0650-20, ATGP0650-50, ATGP0650-100, ATGP0650-250, ATGP0650-500, ATGP0650-1
Lieferbar
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	33.5 kDa (303aa) confirmed by MALDI-TOF
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial, also known as SIRT3, belongs to the sirtuin family of proteins. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance and metabolic regulation. SIRT3 exhibits NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 results in increased levels of the mitochondrial uncoupling protein 1. SIRT3 protein levels are also elevated in certain breast cancers. Recombinant human SIRT3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl
Antigen Species	Human
Gene Category	Cancer
Domain	118-399aa
Species of Protein	Human
Manufacturer - Search Terms	Sirtulin3, SIRT3, NAD-dependent deacetylase sirtuin-3 mitochondrial, SIR2L3, Sirtuin3, NAD-dependent deacetylase sirtuin-3, mitochondrial, ATGP0650-10ug, ATGP0650-20ug, ATGP0650-50ug, ATGP0650-100ug, ATGP0650-250ug, ATGP0650-500ug, ATGP0650-1mg, ATGP0650-10, ATGP0650-20, ATGP0650-50, ATGP0650-100, ATGP0650-250, ATGP0650-500, ATGP0650-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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NKM-ATGP0650-250ug-datasheet.pdf

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Menge: 250 ug

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Lieferung vsl. bis 31.07.2025

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