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Recombinant human Sirtuin 3/SIRT3 protein

Recombinant human Sirtuin 3/SIRT3 protein

Item no.	NKM-ATGP0650-250ug
Manufacturer	NKMAX
Amount	250 ug
Quantity options	10 ug 250 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 95% by SDS-PAGE
Sequence	<MGSSHHHHHH SSGLVPRGSH M>SDKGKLSLQ DVAELIRARA CQRVVVMVGA GISTPSGIPD FRSPGSGLYS NLQQYDLPYP EAIFELPFFF HNPKPFFTLA KELYPGNYKP NVTHYFLRLL HDKGLLLRLY TQNIDGLERV SGIPASKLVE AHGTFASATC TVCQRPFPGE DIRADVMADR VPRCPVCTGV VKPDIVFFGE PLPQRFLLHV VDFPMADLLL ILGTSLEVEP
Citations	Schewr B., et al. (2002) J Cell Biol. 158(4):647-57. Kim H S., et al. (2010) Cancer Cell. 17(1):41-52. Kawaguchi M, et al. Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. (J Med Chem. 2019){https://pubmed.ncbi.nlm.nih.gov/31117516/} Kawaguchi M, et al. A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher. (Chembiochem. 2016){https://pubmed.ncbi.nlm.nih.gov/27542094/}
NCBI	NP_036371.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	NAD-dependent protein deacetylase sirtuin-3 mitochondrial,hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3,SIR2L3
Similar products	SIRT3, mitochondrial, SIR2L3, NAD-dependent deacetylase sirtuin-3, NAD-dependent deacetylase sirtuin-3 mitochondrial, Sirtuin3, Sirtulin3, ATGP0650-10ug, ATGP0650-20ug, ATGP0650-50ug, ATGP0650-100ug, ATGP0650-250ug, ATGP0650-500ug, ATGP0650-1mg, ATGP0650-10, ATGP0650-20, ATGP0650-50, ATGP0650-100, ATGP0650-250, ATGP0650-500, ATGP0650-1
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	33.5 kDa (303aa) confirmed by MALDI-TOF
Description	NAD-dependent deacetylase sirtuin-3, mitochondrial, also known as SIRT3, belongs to the sirtuin family of proteins. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance and metabolic regulation. SIRT3 exhibits NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 results in increased levels of the mitochondrial uncoupling protein 1. SIRT3 protein levels are also elevated in certain breast cancers. Recombinant human SIRT3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl
Antigen Species	Human
Gene Category	Cancer
Domain	118-399aa
Species of Protein	Human
Manufacturer - Search Terms	Sirtulin3, SIRT3, NAD-dependent deacetylase sirtuin-3 mitochondrial, SIR2L3, Sirtuin3, NAD-dependent deacetylase sirtuin-3, mitochondrial, ATGP0650-10ug, ATGP0650-20ug, ATGP0650-50ug, ATGP0650-100ug, ATGP0650-250ug, ATGP0650-500ug, ATGP0650-1mg, ATGP0650-10, ATGP0650-20, ATGP0650-50, ATGP0650-100, ATGP0650-250, ATGP0650-500, ATGP0650-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 ug

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Delivery expected until 7/31/2025

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