Comparison

Recombinant human Sirtuin 3/SIRT3 protein

Item no. NKM-ATGP0650-250ug
Manufacturer NKMAX
Amount 250 ug
Quantity options 10 ug 250 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH M>SDKGKLSLQ DVAELIRARA CQRVVVMVGA GISTPSGIPD FRSPGSGLYS NLQQYDLPYP EAIFELPFFF HNPKPFFTLA KELYPGNYKP NVTHYFLRLL HDKGLLLRLY TQNIDGLERV SGIPASKLVE AHGTFASATC TVCQRPFPGE DIRADVMADR VPRCPVCTGV VKPDIVFFGE PLPQRFLLHV VDFPMADLLL ILGTSLEVEP
Citations Schewr B., et al. (2002) J Cell Biol. 158(4):647-57.
Kim H S., et al. (2010) Cancer Cell. 17(1):41-52.

Kawaguchi M, et al. Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. (J Med Chem. 2019){https://pubmed.ncbi.nlm.nih.gov/31117516/}
Kawaguchi M, et al. A Fluorescent Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of the Dabcyl Quencher. (Chembiochem. 2016){https://pubmed.ncbi.nlm.nih.gov/27542094/}
NCBI NP_036371.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias NAD-dependent protein deacetylase sirtuin-3 mitochondrial,hSIRT3,Regulatory protein SIR2 homolog 3,SIR2-like protein 3,SIR2L3
Similar products SIRT3, mitochondrial, SIR2L3, NAD-dependent deacetylase sirtuin-3, NAD-dependent deacetylase sirtuin-3 mitochondrial, Sirtuin3, Sirtulin3, ATGP0650-10ug, ATGP0650-20ug, ATGP0650-50ug, ATGP0650-100ug, ATGP0650-250ug, ATGP0650-500ug, ATGP0650-1mg, ATGP0650-10, ATGP0650-20, ATGP0650-50, ATGP0650-100, ATGP0650-250, ATGP0650-500, ATGP0650-1
Available
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
33.5 kDa (303aa) confirmed by MALDI-TOF
Description
NAD-dependent deacetylase sirtuin-3, mitochondrial, also known as SIRT3, belongs to the sirtuin family of proteins. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance and metabolic regulation. SIRT3 exhibits NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 results in increased levels of the mitochondrial uncoupling protein 1. SIRT3 protein levels are also elevated in certain breast cancers. Recombinant human SIRT3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl
Antigen Species
Human
Gene Category
Cancer
Domain
118-399aa
Species of Protein
Human
Manufacturer - Search Terms
Sirtulin3, SIRT3, NAD-dependent deacetylase sirtuin-3 mitochondrial, SIR2L3, Sirtuin3, NAD-dependent deacetylase sirtuin-3, mitochondrial, ATGP0650-10ug, ATGP0650-20ug, ATGP0650-50ug, ATGP0650-100ug, ATGP0650-250ug, ATGP0650-500ug, ATGP0650-1mg, ATGP0650-10, ATGP0650-20, ATGP0650-50, ATGP0650-100, ATGP0650-250, ATGP0650-500, ATGP0650-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 250 ug
Available: In stock
available

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