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Recombinant human PPME1 protein

ArtNr NKM-ATGP1150-100ug
Hersteller NKMAX
Menge 100 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF ESMEDVEVEN ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII SRVQCRIVAL DLRSHGETKV KNPEDLSAET MAKDVGNVVE AMYGDLPPPI MLIGHSMGGA IAVHTASSNL VPSLLGLCMI DVVEGTAMDA LNSMQNFLRG RPKTFKSLEN AI
Citations Ogris E. et al. (1999) J. Biol. Chem. 274: 14382-14391.
Gagnon S.N. et al. (2002) Biochem. J. 368:263-271.
NCBI NP_057231
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Protein phosphatase methylesterase 1,FLJ22226,PME-1
Similar products PPME1, Protein phosphatase methylesterase 1, FLJ22226, PME-1, ATGP1150-10ug, ATGP1150-20ug, ATGP1150-50ug, ATGP1150-100ug, ATGP1150-250ug, ATGP1150-500ug, ATGP1150-1mg, ATGP1150-10, ATGP1150-20, ATGP1150-50, ATGP1150-100, ATGP1150-250, ATGP1150-500, ATGP1150-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
44.4 kDa (406aa) confirmed by MALDI-TOF
Description
PPME1, also known protein phosphatase methylesterase-1 (PME1), catalyzes the demethylation and inactivation of protein phosphatase (PP2A), which is a multimeric phosphoserine/ threonine protein phosphatase associated with growth inhibition and cell cycle arrest. It can demethylate PP2A catalytic subunit in vitro and okadaic acid treatment is capable of inhibiting this reaction. It is conserved from yeast to human and contains a motif found in lipases having a catalytic triad activated serine as their active site nucleophile. Recombinant human PPME1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Antigen Species
Human
Gene Category
Signal Transduction
Domain
1-386aa
Species of Protein
Human
Manufacturer - Search Terms
PPME1, Protein phosphatase methylesterase 1, FLJ22226, PME-1, ATGP1150-10ug, ATGP1150-20ug, ATGP1150-50ug, ATGP1150-100ug, ATGP1150-250ug, ATGP1150-500ug, ATGP1150-1mg, ATGP1150-10, ATGP1150-20, ATGP1150-50, ATGP1150-100, ATGP1150-250, ATGP1150-500, ATGP1150-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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