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Recombinant human NKIRAS1 protein

ArtNr NKM-ATGP1412-10ug
Hersteller NKMAX
Menge 10 ug
Quantity options 10 ug 50 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 85% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH> MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD RGVKEQLHLY DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL KKEIDKFKDK KEVAIVVLGN KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP GRKNKGNSNS EN
Citations Fenwick C., et al. (2000) Science. 287:869-873
Chen Y., et al. (2003) J. Biol. Chem. 278:23101-23106
NCBI NP_065078.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias NF-kappa-B inhibitor-interacting Ras-like protein 1,kappaB-Ras1,KBRAS1
Similar products NKIRAS1, KBRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1, kappaB-Ras1, ATGP1412-10ug, ATGP1412-20ug, ATGP1412-50ug, ATGP1412-100ug, ATGP1412-250ug, ATGP1412-500ug, ATGP1412-1mg, ATGP1412-10, ATGP1412-20, ATGP1412-50, ATGP1412-100, ATGP1412-250, ATGP1412-500, ATGP1412-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
23.8 kDa (212aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description
NKIRAS1, also known as NF-kappa-B inhibitor-interacting Ras-like protein 1, belongs to the small GTPase superfamily. NKIRAS1 is atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. It may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Recombinant human NKIRAS1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Concentration
0.25mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT
Antigen Species
Human
Gene Category
Signal Transduction
Domain
1-192aa
Species of Protein
Human
Manufacturer - Search Terms
NKIRAS1, NF-kappa-B inhibitor-interacting Ras-like protein 1, kappaB-Ras1, KBRAS1, ATGP1412-10ug, ATGP1412-20ug, ATGP1412-50ug, ATGP1412-100ug, ATGP1412-250ug, ATGP1412-500ug, ATGP1412-1mg, ATGP1412-10, ATGP1412-20, ATGP1412-50, ATGP1412-100, ATGP1412-250, ATGP1412-500, ATGP1412-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug
Lieferbar: In stock
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