Recombinant human NKp46/NCR1 protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46 ( 22-255aa) was overexpressed in E. coli, and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM EDTA

Immunology

< 1 EU per 1ug of protein (determined by LAL method)

NKp46 Extracellular Ig-like domain, NKp-46 Extracellular Ig-like domain, NKp46, NK p46, NK-p46, NK cell-activating receptor, NCR-1, NCR 1, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen, NCR3001-10ug, NCR3001-20ug, NCR3001-50ug, NCR3001-100ug, NCR3001-250ug, NCR3001-500ug, NCR3001-1mg, NCR3001-010, NCR3001-020, NCR3001-050, NCR3001-100, NCR3001-250, NCR3001-500, NCR3001-01M