Pregnant Mare Serum Gonadotropin ( PMSG )

PMSG is a complex glycoprotein obtained from the serum of pregnant mares. This 43-63 kda protein is capable of supplementing and being substituted for the follicle stimulating gonadotrophin and interstitial cell-stimulating hormone of the anterior pituitary gland in both the male and female. Thus PMSG-Intervet stimulates development of the ovarian follicle in the female.Pregnant mares secrete the hormone from their endometrial cups between 40 and 130 days into their gestation, and once collected, it has been used to artificially induce estrus in female sheep, goats, cattle, and swine. Despite being less pure than pituitary extracts from sheep, goats or swine, PMSG tends to be used because of its longer circulatory half-life. In equids PMSG has only LH like activity, but in other species it has activity like both follicle-stimulating hormone (FSH) and luteinizing hormone (LH).Equine CG, like all glycoprotein hormones, is composed of two dissimilar subunits named alpha and beta. The alpha subunit is common to all glycoprotein hormones (LH, FSH, TSH, CG). The beta subunits are hormone-specific and are responsible for receptor binding specificity, although CG binds to the same Luteinizing hormone/choriogonadotropin receptor as LH. In the equids (horses, donkeys, zebras), the placental CGs and pituitary LH are expressed from the same gene and thus have the same protein sequence, differing only by their carbohydrate side-chains (particularly in their respective beta subunits).

The PMSG was lyophilized with no additives.

Sterile Filtered White lyophilized (freeze-dried) powder.

Endocrinology