HDAC5 Antibody (Center) Blocking Peptide

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been noted for this gene.

10014

Synthetic peptide

The synthetic peptide sequence used to generate the antibody AP1105b was selected from the Center region of human HDAC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.