ALK Antibody (N-term) Blocking peptide

The 2; 5 chromosomal translocation is frequently associatedwith anaplastic large cell lymphomas (ALCLs). The translocationcreates a fusion gene consisting of the ALK (anaplastic lymphomakinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM fromchromosome 5. A recent study shows that the product of the NPM-ALKfusion gene is oncogenic. The deduced amino acid sequences revealthat ALK is a novel receptor protein-tyrosine kinase having aputative transmembrane domain and an extracellular domain. Thesesequences are absent in the product of the transforming NPM-ALKgene. ALK shows the greatest sequence similarity to LTK (leukocytetyrosine kinase). ALK plays an important role in the development ofthe brain and exerts its effects on specific neurons in the nervoussystem.

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Synthetic peptide