TPSAB1 Antibody (C-term) Blocking peptide

Tryptases comprise a family of trypsin-like serineproteases, the peptidase family S1. Tryptases are enzymaticallyactive only as heparin-stabilized tetramers, and they are resistantto all known endogenous proteinase inhibitors. Several tryptasegenes are clustered on chromosome 16p13.3. These genes arecharacterized by several distinct features. They have a highlyconserved 3' UTR and contain tandem repeat sequences at the 5'flank and 3' UTR which are thought to play a role in regulation ofthe mRNA stability. These genes have an intron immediately upstreamof the initiator Met codon, which separates the site oftranscription initiation from protein coding sequence. This featureis characteristic of tryptases but is unusual in other genes. Thealleles of this gene exhibit an unusual amount of sequencevariation, such that the alleles were once thought to represent twoseparate genes, alpha and beta 1. Beta tryptases appear to be themain isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated asmediators in the pathogenesis of asthma and other allergic andinflammatory disorders.

7177

Synthetic peptide