Human Claudin-4 Protein, His,Twin-Streptavidin Tag (Detergent)

Protein

Dry ice

27.5 kDa

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Claudin-4

This protein carries a polyhistidine tag at the N-terminus and a twin streptavidin tag at the C-terminus. The protein has a calculated MW of 27.5 kDa. The protein migrates as 25-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

50 mM Tris, 150 mM NaCl, DDM, CHS, pH7.5

glycerol