Anti-Beclin-1 BECN1 Antibody

Primary Antibodies

51896 MW

WB: 1-2 μg/mL
IHC-P: 2-5 μg/mL
ICC/IF: 10-20 μg/mL
IHC-P/IF: 10-20 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human, mouse, and rat samples; Immunocytochemistry in human samples. All other applications and species not yet tested.

Beclin 1, autophagy related

Anti-Beclin-1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human Beclin-1. The immunogen is located between 40-90 amino acids of Beclin-1.

Beclin-1 Antibody is affinity chromatography purified via peptide column.

Apoptosis, Autophagy, Cancer

Plays a central role in autophagy (PubMed:23184933,
PubMed:28445460). Acts as core subunit of the PI3K complex that
mediates formation of phosphatidylinositol 3-phosphate; different
complex forms are believed to play a role in multiple membrane
trafficking pathways: PI3KC3-C1 is involved in initiation of
autophagosomes and PI3KC3-C2 in maturation of autophagosomes and
endocytosis. Involved in regulation of degradative endocytic
trafficking and required for the abcission step in cytokinesis,
probably in the context of PI3KC3-C2 (PubMed:20643123,
PubMed:20208530, PubMed:26783301). Essential for the formation of
PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in
endocytosis (PubMed:25275521). Protects against infection by a
neurovirulent strain of Sindbis virus (PubMed:9765397). May play a
role in antiviral host defense.

Boster Bio Anti-Beclin-1 BECN1 Antibody (Catalog # A00327-1). Tested in ELISA, WB, ICC/IF, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-Beclin-1 BECN1 Antibody (Catalog # A00327-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.