GHBP

ArtNr	cyt-238-5ug
Hersteller	ProSpec
Menge	5 ug
Quantity options	1 mg 20 ug 5 ug
Kategorie	Neuroscience Metabolism Diabetes Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins
Typ	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Purity	Greater than 98.0% as determined by:<BR>(a) Analysis by SEC-HPLC.<BR>(b) Analysis by SDS-PAGE.
Sequence	afsgseataai lsrapwslqs vnpglktnss kepkftkcrs peretfschw tdevhhgtkn lgpiqlfytr rntqewtqew kecpdyvsag enscyfnssf tsiwipycik ltsnggtvde kcfsvdeivq pdppialnwt llnvsltgih adiqvrweap rnadiqkgwm vleyelqyke vnetkwkmmd pilttsvpvy slkvdkeyev rvrskqrnsg nygefsevly v
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	GHBP,GHR,GHBP,GH receptor,Somatotropin receptor
Similar products	GHBP
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Manufacturer - Category	CYTOKINES AND GROWTH FACTORS
Storage Conditions	Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution GHBP should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Description	Recombinant Human Growth Hormone Binding Protein
Formulation	GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
Introduction	GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Biological Activity	GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
Manufacturer - Format	Sterile Filtered White lyophilized (freeze-dried) powder.

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cyt-238-5ug-safety-datasheet.pdf