Manufacturer |
ProSpec
|
Category |
|
Type |
Cytokines and Growth Factors |
Specific against |
Human |
Amount |
5ug |
Item no. |
cyt-238-5ug |
eClass 6.1 |
32161000 |
eClass 9.0 |
42030690 |
Available |
|
Synonyms |
GHR, GHBP, GH receptor, Somatotropin receptor |
Introduction |
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. |
Description |
Growth Hormone Binding Protein Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28107.01 Dalton. GHR is purified by proprietary chromatographic techniques. |
Source |
Escherichia Coli. |
Physical Appearance |
Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation |
GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3. |
Purity |
Greater than 98.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE. |
Usage |
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Amino acid sequence |
afsgseataai lsrapwslqs vnpglktnss kepkftkcrs peretfschw tdevhhgtkn lgpiqlfytr rntqewtqew kecpdyvsag enscyfnssf tsiwipycik ltsnggtvde kcfsvdeivq pdppialnwt llnvsltgih adiqvrweap rnadiqkgwm vleyelqyke vnetkwkmmd pilttsvpvy slkvdkeyev rvrskqrnsg nygefsevly vtlpqmsq. |
Biological Activity |
GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH. |
Storage |
Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution GHBP should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.