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Recombinant Human Tissue Plasminogen Activator

Recombinant Human Tissue Plasminogen Activator

ArtNr	enz-263-100ug
Hersteller	ProSpec
Menge	100ug
Kategorie	Food Safety Proteins Peptides & Proteins Enzymes
Typ	Enzymes
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Similar products	tPA
Lieferbar
Synonyms	Tissue-type plasminogen activator, EC 3 4 21 68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148
Introduction	Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine proteasewhich converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism.
Description	Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59008.71 Dalton. tPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques.
Source	Chinese Hamster Ovary Cells (CHO) Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	Each mg of t-PA contains 1.7 gr L-arginine, 0.5 gr phosphoric acid and 4 mg tween 80.
Purity	Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage	Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution tPA should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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enz-263-100ug-safety-datasheet.pdf