Human TGFBR2 Protein, hFc Tag

ECD Proteins

C-Human Fc Tag, Unconjugated

The protein has a predicted molecular mass of 41.6 kDa after removal of the signal peptide. The apparent molecular mass of TGFBR2-hFc is approximately 55-70 kDa due to glycosylation.

affinity purification

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]

Recombinant human TGFBR2 protein with C-terminal human Fc tag

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.