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Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

ArtNr	ILC-H5257-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 500 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, Fc
Purity	95%
Citations	(1) Dean Toy. et al.,J Immunol. 2006 Jul 1;177(1):36-9. (2) Jill F Wright. et al.,J Immunol. 2008 Aug 15;181(4):2799-805. (3) Vladimir Ramirez-Carrozzi. et al.,Nat Immunol. 2011 Oct 12;12(12):1159-66.
NCBI	NP_703190.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-17 RA & IL-17 RC,IL-17RA & IL-17RC,CD217 & IL-17 RC
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Cytokines&Growth Factors
Manufacturer - Conjugate / Tag	C-Fc \| C-Fc, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	60.0 kDa (IL-17 RA) & 75.7 kDa (IL-17 RC)
Manufacturer - Format	Powder
Description	Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (ILC-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)).
Background	Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Molecule	IL-17 RA & IL-17 RC
Exp Region	Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC)
Characteristics	Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag is produced by co-expression of IL-17RA and IL-17RC, has a calculated MW of 60.0 kDa (IL-17RA) & 75.7 kDa (IL-17RC). Subunit IL-17RA is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-17RC is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 80-90 kDa and 100-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	●-20 to -70°C for 12 months in lyophilized state from date of receipt; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

ILC-H5257-100ug-datasheet.pdf

ILC-H5257-100ug-safety-datasheet.pdf