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Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

Item no.	ILC-H5257-100ug
Manufacturer	ACROBiosystems
Amount	100 ug
Quantity options	100 ug 500 ug x 2
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	Unconjugated, Fc
Purity	95%
Citations	(1) Dean Toy. et al.,J Immunol. 2006 Jul 1;177(1):36-9. (2) Jill F Wright. et al.,J Immunol. 2008 Aug 15;181(4):2799-805. (3) Vladimir Ramirez-Carrozzi. et al.,Nat Immunol. 2011 Oct 12;12(12):1159-66.
NCBI	NP_703190.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-17 RA & IL-17 RC,IL-17RA & IL-17RC,CD217 & IL-17 RC
Shipping Condition	Room temperature
Available
Manufacturer - Category	Protein / Cytokines&Growth Factors
Manufacturer - Conjugate / Tag	C-Fc \| C-Fc, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	60.0 kDa (IL-17 RA) & 75.7 kDa (IL-17 RC)
Manufacturer - Format	Powder
Description	Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (ILC-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)).
Background	Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Molecule	IL-17 RA & IL-17 RC
Exp Region	Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC)
Characteristics	Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag is produced by co-expression of IL-17RA and IL-17RC, has a calculated MW of 60.0 kDa (IL-17RA) & 75.7 kDa (IL-17RC). Subunit IL-17RA is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-17RC is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 80-90 kDa and 100-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	●-20 to -70°C for 12 months in lyophilized state from date of receipt; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ILC-H5257-100ug-datasheet.pdf

ILC-H5257-100ug-safety-datasheet.pdf