Interleukin-25/IL-25

Ambient

Recombinant Human Interleukin-25/IL-25 is produced with our E. coli expression system. The target protein is expressed with sequence (Tyr33-Gly177) of Human IL-25.

Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted & are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production & are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils & basophils, & present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, & the cross-linking induces NF-kappaB activation & production of the proinflammatory chemokine IL-8, as well as ERK, JNK, & p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic & immune functions, & additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance & functions of adaptive Th2 memory cells. Human IL-17E cDNA encodes a 177 amino acid residues precursor protein with a putative 32 amino acid signal peptide. A second isoform of human IL-17E encoding a 161 amino acid precursor protein also exists.