[Novoprotein] Recombinant Human C-X-C Motif Chemokine 11/CXCL11

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Recombinant Human C-X-C Motif Chemokine 11 is produced by our E.coli expression system & the target gene encoding Phe22-Phe94 is expressed.

Chemokine Ligand 11 (CXCL11) is a non-ELR (lacking the Glu-Leu-Arg tripeptide motif) CXC chemokine. CXCL11 is highly expressed in peripheral blood leukocytes, pancreas & liver, with moderate levels in thymus, spleen & lung & low expression levels were in small intestine, placenta & prostate. Gene expression of CXCL11 is strongly induced by IFN-gamma & IFN-beta, & weakly induced by IFN-alpha. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 & CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family. CXCL11 cDNA encodes a 94 amino acid residue precursor protein with a 21 amino acid residue putative signal sequence, which is cleaved to form the mature 73 amino acid residue protein. CXCL11 shares 36% & 37% amino acid sequence homology with IP-10 & MIG (two other known human non-ELR CXC chemokines), respectively. Mouse CXCL11 exhibits 68% sequence homology with humanCXCL11. In humans, CXCL11, IP-10 & MIG all map to the same locus on chromosome 4.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.