Recombinant Human Bone Morphogenetic Protein 9/BMP-9/GDF-2 (C-6His)

Lyophilized protein should be stored at < -20C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20C for 3 months.

Recombinant Human Growth & differentiation factor 2 is produced by our Mammalian expression system & the target gene encoding Ser320-Arg429 is expressed with a 6His tag at the C-terminus.

Bone morphogenetic protein 9 (BMP9), also known as growth differentiation factor-2, is a member of the TGFbeta superfamily proteins that bind to type II & type I serine-threonine kinase receptors, & transduces signals through Smad & non-Smad signalling pathways. BMP9 has been shown to be a potent synergistic factor for hematopoietic progenitor generation & colony formation & may play a role in the induction & maintenance of the neuronal cholinergic phenotype in the central nervous system. ALK1 & ALK2 are important receptors for BMP9-induced osteogenic differentiation both in vitro & in vivo. BMP9 is highly expressed in the developing mouse liver, & recombinant human BMP9 stimulates hepatocyte proliferation.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.