Mouse SEMA3A/Semaphorin-3A Protein (SEM-MM13A)

SEMA3A/Semaphorin-3A

Shipped with dry ice.

The protein has a predicted MW of 86.6 kDa. Due to furin cleavage site, the protein migrates to 65-70 kDa based on Bis-Tris PAGE result.

The CRMP proteins were originally identified as mediators of Sema3A signaling and neuronal differentiation. Much has been learned about the mechanism by which CRMPs regulate cellular responses to Sema3A.The secreted protein Sema3A (collapsin-1) was the first identified vertebrate semaphorin. Sema3A acts primarily as a repulsive axon guidance cue, and can cause a dramatic collapse of the growth cone lamellipodium.Neuropilin-1 (NP1) and members of the class A plexins (PlexA) form a Sema3A receptor complex, with NP1 serving as a high-affinity ligand binding partner, and PlexA transducing the signal into the cell via its large intracellular domain.

Supplied as 0.22 μm filtered solution in PBS, 200 mM L-Argine (pH 7.4).

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