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Anti-Histone H3 Rabbit mAb

ArtNr PTM-6613
Hersteller PTM Biolabs
Menge 100 ul
Kategorie
Typ Antibody Monoclonal
Format Lyophilized powder
Applikationen WB, IHC-P
Clon JMMR-2423B
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Monkey (Cynomolgus, Simian)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
Citations Xiao Cheng, et al. Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis. iScience, 2024. https://www.cell.com/iscience/fulltext/S2589-0042(24)01501-3.
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Histone H3.1,Histone H3/a,H3C1,H3FA,HIST1H3A,Histone H3/b,Histone H3/c,Histone H3/d
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Primary Antibodies
Manufacturer - Category
Histone & Histone Modification Antibodies, Loading Control Antibodies
Manufacturer - Targets
Histone H3
Shipping Temperature
Ambient temperature
Storage Conditions
Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight
15
Stability
Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area
Epigenetics
Product description
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
Purification Method
Protein A purified
Manufacturer - Specificity
Anti-Histone H3 Rabbit mAb detects endogenous levels of total histone H3 protein. It does not cross-react with other histone or non-histone proteins.
Formula
PBS, Glycerol, BSA
PTM
Unmodified
Immunogen
Synthetic peptide derived from human histone H3 protein
Clonality
Recombinant Monoclonal
Background
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.
Cellular Localization
Nucleus

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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