Anti-AIFM2/FSP1 Mouse mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

AIF-homologous mitochondrion-associated inducer of death (AMID), also known as Apoptosis-inducing factor mitochondria-associated 2 (AIFM2) or p53-responsive gene 3 (PRG3), is a homolog of apoptosis-inducing factor (AIF). Research studies show that it inhibits ferroptosis, a form of cell death caused by iron-dependent lipid peroxidation. Therefore, this protein was named as ferroptosis suppressor protein 1 (FSP1). FSP1 is a CoQ oxidoreductase and generates the reduced form of coenzyme Q10, which traps lipid peroxides, leading to the suppression of ferroptosis. Furthermore, inhibition of ferroptosis by FSP1 was shown to be independent of GPX4, another negative regulator of ferroptosis.

PBS, Glycerol, BSA

Recombinant Monoclonal

Cytoplasm, Cell membrane, Nucleus, Mitochondrion membrane