RSK1, Active

ArtNr	268-11273-1
Hersteller	Raybiotech
Menge	5 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	other
Host	Hamster - Armenian
Purity	>90% determined by SDS-PAGE
Dry ice	Yes
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	RSK,ribosomal s6 kinase (rsk),pp90RSK4
Versandbedingung	Trockeneis
Lieferbar
Manufacturer - Category	Recombinant Protein
Storage Conditions	The protein may be stored for 12 months at -80° C
Molecular Weight	108.0 kDa
Gene Symbols	RSK
Concentration	5µ g/50 µ l
Biological activity	38 nmol phosphate incorporated into S6K substrate peptide minute per mg protein at 30° C for 15 minutes using a final concentration of 50 µ M ATP (0.83 µ Ci/assay).
Introduction	The RSK (ribosomal S6 kinase) family comprises growth factor-regulated serine/threonine kinases, known also as p90(rsk). RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. Moller described the cloning and characterization of 3 genes encoding RSKs, and HU1 (also named RPS6KA1, or RSK1) cDNA encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. Northern blot and RNase protection analyses detected an approximately 3.5-kb HU1 transcript in lymphocytes, skeletal muscle, liver, and adipose tissue (1). Zeniou determined the expression of the RSK1, RSK2, and RSK3 genes in various human tissues, during mouse embryogenesis, and in mouse brain (2). RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation (3).
Country of Animal Origin	USA

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