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Recombinant human Hexokinase 2 protein

ArtNr NKM-HXK0703-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 85% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH> MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR GSGTQLFDHI AECLANFMDK LQIKDKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV EGRDVVALIR KAIQRRGDFD IDIVAVVNDT
Citations Jon E. et al.,(2003) J.Exp Biology. 206 : 2049-2057.
Furuta H. et al.,(1996) Genomics. 36(1):206-9.

Wuest M, et al. Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-D-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer. (Nucl Med Biol. 2011){https://pubmed.ncbi.nlm.nih.gov/21531283/}
Tsumura Y, et al. TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models. (PLoS One. 2017){https://pubmed.ncbi.nlm.nih.gov/28207836/}
Ciscato F, et al. Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca 2+ -dependent death of cancer cells. (EMBO Rep. 2020){https://pubmed.ncbi.nlm.nih.gov/32383545/}
NCBI NP_000180
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias HK2,Hexokinase 2,EC 2.7.1.1,Hexokinase type II,HK II,Muscle form hexokinase,Hexokinase-2,hexokinase 2
Similar products HK2, Hexokinase-2, Hexokinase type II, Muscle form hexokinase, Hexokinase 2, HK II, EC 2.7.1.1, hexokinase 2, Hexokinase2, HXK0703-10ug, HXK0703-20ug, HXK0703-50ug, HXK0703-100ug, HXK0703-250ug, HXK0703-500ug, HXK0703-1mg, HXK0703-10, HXK0703-20, HXK0703-50, HXK0703-100, HXK0703-250, HXK0703-500, HXK0703-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Enzyme Activity
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
104.1 kDa (937aa)
Description
Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase2 is found in the skeletal muscle and includes hydrophobic N-terminal sequence capable of targeting the hexokinase to mitochondria. Recombinant human Hexokinase2, fused to His tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Antigen Species
Human
Gene Category
Signal Transduction
Domain
1-917aa
Bioactivity Comment Only
Specific activity is > 12, 000pmol/min/ug. One unit will convert 1pmole of D-Glucose to D-Glucose-6-phosphate per minute at pH8.0 at 37C.
Species of Protein
Human
Manufacturer - Search Terms
Hexokinase2, HK2, Hexokinase 2, EC 2.7.1.1, Hexokinase type II, HK II, Muscle form hexokinase, Hexokinase-2, hexokinase 2, HXK0703-10ug, HXK0703-20ug, HXK0703-50ug, HXK0703-100ug, HXK0703-250ug, HXK0703-500ug, HXK0703-1mg, HXK0703-10, HXK0703-20, HXK0703-50, HXK0703-100, HXK0703-250, HXK0703-500, HXK0703-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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